In Vitro Bioactivity and Antimicrobial Tuning of Bioactive Glass Nanoparticles Added with Neem Azadirachta indica Leaf PowderReport as inadecuate




In Vitro Bioactivity and Antimicrobial Tuning of Bioactive Glass Nanoparticles Added with Neem Azadirachta indica Leaf Powder - Download this document for free, or read online. Document in PDF available to download.

BioMed Research International - Volume 2014 2014, Article ID 950691, 10 pages -

Research Article

Centre for Nanoscience and Technology, K. S. Rangasamy College of Technology, Tiruchengode, Namakkal District, Tamil Nadu 637215, India

Department of Mechanical Engineering, K. S. Rangasamy College of Technology, Tiruchengode, Namakkal District, Tamil Nadu 637215, India

Received 6 February 2014; Revised 10 July 2014; Accepted 24 July 2014; Published 7 September 2014

Academic Editor: Kibret Mequanint

Copyright © 2014 M. Prabhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Silica and phosphate based bioactive glass nanoparticles 58SiO2-33CaO-9P2O5 with doping of neem Azadirachta indica leaf powder and silver nanoparticles were prepared and characterised. Bioactive glass nanoparticles were produced using sol-gel technique. In vitro bioactivity of the prepared samples was investigated using simulated body fluid. X-ray diffraction XRD pattern of prepared glass particles reveals amorphous phase and spherical morphology with a particle size of less than 50 nm. When compared to neem doped glass, better bioactivity was attained in silver doped glass through formation of hydroxyapatite layer on the surface, which was confirmed through XRD, Fourier transform infrared FTIR, and scanning electron microscopy SEM analysis. However, neem leaf powder doped bioactive glass nanoparticles show good antimicrobial activity against Staphylococcus aureus and Escherichia coli and less bioactivity compared with silver doped glass particles. In addition, the biocompatibility of the prepared nanocomposites reveals better results for neem doped and silver doped glasses at lower concentration. Therefore, neem doped bioactive glass may act as a potent antimicrobial agent for preventing microbial infection in tissue engineering applications.





Author: M. Prabhu, S. Ruby Priscilla, K. Kavitha, P. Manivasakan, V. Rajendran, and P. Kulandaivelu

Source: https://www.hindawi.com/



DOWNLOAD PDF




Related documents