Consistency of Mycobacterium tuberculosis-Specific Interferon-Gamma Responses in HIV-1-Infected Women during Pregnancy and PostpartumReport as inadecuate




Consistency of Mycobacterium tuberculosis-Specific Interferon-Gamma Responses in HIV-1-Infected Women during Pregnancy and Postpartum - Download this document for free, or read online. Document in PDF available to download.

Infectious Diseases in Obstetrics and GynecologyVolume 2012 2012, Article ID 950650, 7 pages

Clinical Study

Department of Epidemiology, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA

Department of Biostatistics, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA

Department of Medicine, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA

Department of Global Health, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA

Department of Paediatrics, University of Nairobi, P.O. Box 19676, Nairobi 00100, Kenya

Department of Pediatrics, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA

Received 17 November 2011; Accepted 3 January 2012

Academic Editor: Susan Cu-Uvin

Copyright © 2012 Sasi R. Jonnalagadda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. We determined the consistency of positive interferon-gamma IFN-γ release assays IGRAs to detect latent TB infection LTBI over one-year postpartum in HIV-1-infected women. Methods. Women with positive IGRAs during pregnancy had four 3-monthly postpartum IGRAs. Postpartum change in magnitude of IFN-γ response was determined using linear mixed models. Results. Among 18 women with positive pregnancy IGRA, 15 83% had a subsequent positive IGRA; 9 50% were always positive, 3 17% were always negative, and 6 33% fluctuated between positive and negative IGRAs. Women with pregnancy IGRA IFN-γ spot forming cells SFCs-well were more likely to have consistent postpartum IGRA response odds ratio: 10.0; 95% confidence interval CI: 0.9–117.0. Change in IFN-γ response over postpartum was 10.2 SFCs-well 95% CI: −1.5–21.8 SFCs-well. Conclusion. Pregnancy positive IGRAs were often maintained postpartum with increased consistency in women with higher baseline responses. There were modest increases in magnitude of IGRA responses postpartum.





Author: Sasi R. Jonnalagadda, Elizabeth Brown, Barbara Lohman-Payne, Dalton Wamalwa, Carey Farquhar, Kenneth Tapia, Lisa M. Cranmer,

Source: https://www.hindawi.com/



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