Detection of volume loss in hippocampal layers in Alzheimers disease using 7 T MRI: a feasibility studyReport as inadecuate

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1 Service de neuro-radiologie CHU Pitié-Salpêtrière 2 ARAMIS - Algorithms, models and methods for images and signals of the human brain Inria Paris-Rocquencourt, UPMC - Université Pierre et Marie Curie - Paris 6, ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute 3 CRICM - Centre de Recherche de l-Institut du Cerveau et de la Moelle épinière 4 IM2A - Institut de la Mémoire et de la Maladie d-Alzheimer Paris 5 NEUROSPIN - Service NEUROSPIN 6 AP-HP - Hôpital Cochin Broca Hôtel Dieu Paris

Abstract : In Alzheimer-s disease AD, the hippocampus is an early site of tau pathology and neurodegeneration. Histological studies have shown that lesions are not uniformly distributed within the hippocampus. Moreover, alterations of different hippocampal layers may reflect distinct pathological processes. 7 T MRI dramatically improves the visualization of hippocampal subregions and layers. In this study, we aimed to assess whether 7 T MRI can detect volumetric changes in hippocampal layers in vivo in patients with AD. We studied four AD patients and seven control subjects. MR images were acquired using a whole-body 7 T scanner with an eight channel transmit-receive coil. Hippocampal subregions were manually segmented from coronal T2*-weighted gradient echo images with 0.3 × 0.3 × 1.2 mm3 resolution using a protocol that distinguishes between layers richer or poorer in neuronal bodies. Five subregions were segmented in the region of the hippocampal body: alveus, strata radiatum, lacunosum and moleculare SRLM of the cornu Ammonis CA, hilum, stratum pyramidale of CA and stratum pyramidale of the subiculum. We found strong bilateral reductions in the SRLM of the cornu Ammonis and in the stratum pyramidale of the subiculum p < 0.05, with average cross-sectional area reductions ranging from -29% to -49%. These results show that it is possible to detect volume loss in distinct hippocampal layers using segmentation of 7 T MRI. 7 T MRI-based segmentation is a promising tool for AD research.

Author: Claire Boutet - Marie Chupin - Stéphane Lehéricy - Linda Marrakchi-Kacem - Stéphane Epelbaum - Cyril Poupon - Christopher Wigg



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