Spectroscopic Characterization and Biological Activity of Mixed Ligand Complexes of NiII with 1,10-Phenanthroline and Heterocyclic Schiff BasesReport as inadecuate




Spectroscopic Characterization and Biological Activity of Mixed Ligand Complexes of NiII with 1,10-Phenanthroline and Heterocyclic Schiff Bases - Download this document for free, or read online. Document in PDF available to download.

Bioinorganic Chemistry and ApplicationsVolume 2012 2012, Article ID 948534, 8 pages

Research Article

Department of Chemistry, Osmania University, Hyderabad 500 007, India

Indian Institute of Chemical Technology, Hyderabad 500 007, India

Centre for Cellular and Molecular Biology, Hyderabad 500 007, India

Received 9 April 2012; Revised 18 July 2012; Accepted 27 July 2012

Academic Editor: Imre Sovago

Copyright © 2012 Y. Prashanthi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mixed ligand complexes of NiII with 1,10-phenanthroline 1,10-Phen and Schiff bases L1MIIMP; L2CMIIMP; L3EMIIMP; L4MIIMNP; L5MEMIIMP; L6BMIIMP; L7MMIIMP; L8MIIBD have been synthesized. These metal chelates have been characterized by elemental analysis, IR,

H-NMR,

C-NMR, Mass, UV-Vis, magnetic moments, and thermogravimetric TGandDTA analysis. Spectral data showed that the 1,10-phenanthroline act as neutral bidentate ligand coordinating to the metal ion through two nitrogen donor atoms and Schiff bases acts as monobasic bidentate coordinating through NO donor atoms. All NiII complexes appear to have an octahedral geometry. The antimicrobial activity of mixed ligand complexes has been studied by screening against various microorganisms, it is observed that the activity enhances upon coordination. The DNA binding studies have been investigated by UV-Vis spectroscopy, and the experimental results indicate that these complexes bind to CT DNA with the intrinsic binding constant  M

. MTT is used to test the anticancer effect of the complexes with HL60 tumor cell. The inhibition ratio was accelerated by increasing the dosage, and it had significant positive correlation with the medication dosage.





Author: Y. Prashanthi, K. Kiranmai, Ira, Sathish kumar K, Vijay kumar Chityala, and Shivaraj

Source: https://www.hindawi.com/



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