Differences of IL-1β Receptors Expression by Immunocompetent Cells Subsets in Rheumatoid ArthritisReport as inadecuate




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Mediators of Inflammation - Volume 2015 2015, Article ID 948393, 9 pages -

Research Article

Federal State Budgetary Scientific Institution -Research Institute of Fundamental and Clinical Immunology-, Yadrintsevskaya Street 14, Novosibirsk 630099, Russia

I.M. Sechenov First Moscow State Medical University of the Ministry of Health, Bolshaya Pirogovskaya Street 2-4, Moscow 119991, Russia

Received 20 February 2015; Accepted 27 August 2015

Academic Editor: Elena Voronov

Copyright © 2015 Alina A. Alshevskaya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

IL-1β is involved in the induction and maintenance of chronic inflammation in rheumatoid arthritis RA. Its activity is regulated and induced by soluble and membrane-bound receptors, respectively. The effectiveness of the cytokine depends not only on the percentage of receptor-positive cells in an immunocompetent subset but also on the density of receptor expression. The objective of this study was to investigate the expression of IL-1β membrane-bound receptors IL-1R1 and IL-1R2 in terms of the percentage of receptor-positive cells and the number of receptors per cell in different subsets of immune cells in RA patients before and after a course of basic excluding anticytokine therapy and in healthy individuals. The resulting data indicate differences in the expression of IL-1β receptors among T cells, B cells, and monocytes in healthy volunteers and in rheumatoid arthritis patients. The importance of determining both the relative percentage of cells expressing receptors to immunomodulatory cytokines and the number of membrane-bound receptors per cell is highlighted by evidence of unidirectional or multidirectional changing of these parameters according to cell subset and health status.





Author: Alina A. Alshevskaya, Julia A. Lopatnikova, Nadezhda S. Shkaruba, Oksana A. Chumasova, Aleksey E. Sizikov, Aleksander V. Kara

Source: https://www.hindawi.com/



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