A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen TherapyReport as inadecuate




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Case Reports in HematologyVolume 2012 2012, Article ID 948351, 3 pages

Case ReportSeidman Cancer Center, University Hospitals Case Medical Center and Division of Hematology and Oncology, Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, WRB2-130, Cleveland, OH 44106-7284, USA

Received 20 November 2012; Accepted 6 December 2012

Academic Editors: H. Guglielmone, M.-C. Kyrtsonis, Y. Matsukawa, and Y. Shiozawa

Copyright © 2012 Lalitha Nayak and Alvin H. Schmaier. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The antiestrogenic drug tamoxifen, used in patients with breast cancer, is associated with an increase in arterial and venous thrombotic events, the mechanism of which is not clearly understood. We report a case of a lady who presented with new bruising and prolonged bleeding following a tooth extraction 4–6 weeks after starting tamoxifen. Investigations were consistent with an acquired platelet storage pool disorder. Repeat platelet function analysis was normal, performed 3 months after discontinuation of tamoxifen. We present a previously clinically unreported effect of tamoxifen on platelet function.





Author: Lalitha Nayak and Alvin H. Schmaier

Source: https://www.hindawi.com/



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