Level of agreement between 2002 American-European Consensus Group and 2012 American College of Rheumatology classification criteria for Sjogrens syndrome and reasons for discrepancies.Report as inadecuate




Level of agreement between 2002 American-European Consensus Group and 2012 American College of Rheumatology classification criteria for Sjogrens syndrome and reasons for discrepancies. - Download this document for free, or read online. Document in PDF available to download.

1 EA2216 - Immunologie et Pathologie 2 CHU - BREST - Rhumato - CHRU Brest - Service de Rhumatologie 3 Optimisation Continue des Actions Thérapeutiques par l-Intégration d-Informations Multimodales 4 LabEX IGO Immunothérapie Grand Ouest 5 Laboratoire d-Immunologie et Immunothérapie

Abstract : The aims of this study were to assess agreement between the currently used 2002 American-European Consensus Group AECG classification criteria and the new 2012 American College of Rheumatology ACR criteria for Sjogren-s syndrome SS and to identify potential sources of disagreement. METHODS: We studied 105 patients between 2006 and 2013 from the Brittany cohort of patients with suspected SS. AECG criteria were applied using only Schimer-s test and unstimulated whole salivary flow UWSF to assess objective ocular and oral involvement, since these are the tests most physicians use in clinical practice. Agreement between the two sets of criteria was assessed using Cohen-s kappa coefficient. RESULTS: Of those studied, 42 patients fulfilled AECG and 35 ACR criteria. Agreement between the two sets was moderate kappa = 0.53. Patients fulfilling ACR but not AECG criteria n = 8 were significantly younger and had shorter symptom durations, but only three of them had SS in the opinion of the evaluating physician. Xerostomia and xerophthalmia AECG set only did not discriminate between patients with and without SS. The use of UWSF in the AECG but not the ACR criteria explained part of the disagreement. The serological item in the ACR set positive rheumatoid factor and antinuclear antibody >=1:320 or anti-SSA-SSB positivity did not result in classification differences compared to anti-SSA-SSB antibody alone AECG set. Agreement between ocular staining score >=3 ACR set and Schirmer-s test



Author: Divi Cornec - Alain Saraux - Béatrice Cochener - Jacques-Olivier Pers - Sandrine Jousse-Joulin - Yves Renaudineau - Thierry Marh

Source: https://hal.archives-ouvertes.fr/



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