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Bone Marrow ResearchVolume 2012 2012, Article ID 916479, 5 pages

Review ArticleUniversity of Texas MD Anderson Cancer Center, Houston, TX 77030-4009, USA

Received 22 November 2011; Accepted 23 February 2012

Academic Editor: Luciano J. Costa

Copyright © 2012 Raymond Alexanian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Among 792 patients with multiple myeloma treated from 1987 to 2010 and assessed after 18 months, there were 167 patients with complete remission. For those 60 patients treated between 1987–1998 and with long followup, the latest relapse occurred after 11.8 years, so that 13 patients have remained in sustained complete remission for longer than 12 years range 12–22 years. These results suggest that 3% of all patients treated during that period may be cured of multiple myeloma. In addition to immunofixation, more sensitive techniques for the detection of residual disease should be applied more consistently in patients with apparent complete remission in order to identify those with potential cure.

Author: Raymond Alexanian, Kay Delasalle, Michael Wang, Sheeba Thomas, and Donna Weber



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