Overexpression of Gastrin-Releasing Peptide Receptors in Tumor-Associated Blood Vessels of Human Ovarian NeoplasmsReportar como inadecuado

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Cellular Oncology - Volume 29 2007, Issue 5, Pages 421-433

Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Berne, CH-3010 Berne, Switzerland

Copyright © 2007 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background: Peptide receptors, overexpressed in specific cancers, represent new diagnostic and therapeutic targets. In this study, receptors for the gastrin-releasing peptide GRP, and other members of the bombesin-family of peptides, were evaluated in ovarian neoplasms. Methods: 75 primary, secondary and metastatic ovarian tumors were investigated for their bombesin-receptor subtype expression, incidence, localization and density using in vitro autoradiography on tissue sections with the universal radioligand


, ß-Ala

, Phe

, Nle14-bombesin6-14 and the GRP-receptor subtype-preferring


-bombesin. Results: GRP-receptors were detected in 42-61 primary ovarian tumors; other bombesin-receptor subtypes BB1, bb3 were rarely present 3-61. Two different tissue compartments expressed GRP-receptors: the tumoral vasculature was the predominant site of GRP-receptor expression 38-61, whereas neoplastic cells more rarely expressed GRP-receptors 14-61. GRP-receptor positive vessels were present in the various classes of ovarian tumors; generally, malignant tumors had a higher incidence of GRP-receptor positive vessels compared to their benign counterparts. The prevalence of such vessels was particularly high in ovarian carcinomas 16-19 and their metastases 5-5. The GRP-receptors were expressed in high density in the muscular vessel wall. Normal ovary n=10 lacked GRP-receptors. Conclusions: The large amounts of GRP-receptors in ovarian tumor vessels suggest a role in tumoral vasculature and possibly angiogenesis. Further, these vessels might be targeted in vivo with bombesin analogs for diagnosis or for therapy.

Autor: Achim Fleischmann, Beatrice Waser, and Jean Claude Reubi

Fuente: https://www.hindawi.com/


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