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Genome Integrity

, 3:10

Non-homologous end joining and human disease

Abstract

The non-homologous end joining pathway is essential for efficient repair of chromosome double strand breaks. This pathway consequently plays a key role in cellular resistance to break-inducing exogenous agents, as well as in the developmentally-programmed recombinations that are required for adaptive immunity. Chromosome breaks often have complex or -dirty- end structures that can interfere with the critical ligation step in this pathway; we review here how non-homologous end joining resolves such breaks.

KeywordsDouble strand break repair non-homologous end joining DNA damage Ionizing radiation Electronic supplementary materialThe online version of this article doi:10.1186-2041-9414-3-10 contains supplementary material, which is available to authorized users.

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Autor: Natasha Tiffany Strande - Crystal Ann Waters - Dale A Ramsden

Fuente: https://link.springer.com/article/10.1186/2041-9414-3-10



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