Synthesis and Properties of Flexible Polyurethane Using Ferric Catalyst for Hypopharyngeal Tissue EngineeringReportar como inadecuado

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BioMed Research International - Volume 2015 2015, Article ID 798721, 11 pages -

Research Article

Lihuili Hospital of Ningbo University, Ningbo 315040, China

The Medical School of Ningbo University, Ningbo 315211, China

School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798

Received 1 April 2015; Revised 5 June 2015; Accepted 14 June 2015

Academic Editor: Kadriye Tuzlakoglu

Copyright © 2015 Zhisen Shen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Biodegradable polyurethane is an ideal candidate material to fabricate tissue engineered hypopharynx from its good mechanical properties and biodegradability. We thus synthesized a hydrophilic polyurethane via reactions among polyethylene glycol PEG, e-caprolactone e-CL and hexamethylene diisocyanate HDI, and thrihydroxymethyl propane TMP. The product possessed a fast degradability due to its good wettability and good mechanical parameters with the elongations at break 137 ± 10% and tensile strength 4.73 ± 0.46 MPa, which will make it a good matrix material for soft tissue like hypopharynx. Its biological properties were evaluated via in vitro and in vivo tests. The results showed that this hydrophilic polyurethane material can support hypopharyngeal fibroblast growth and owned good degradability and low inflammatory reaction in subcutaneous implantation. It will be proposed as the scaffold for hypopharyngeal tissue engineering research in our future study.

Autor: Zhisen Shen, Jian Wang, Dakai Lu, Qun Li, Chongchang Zhou, Yabin Zhu, and Xiao Hu



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