Comparison of Fine Needle Aspiration Cytology and Thyroid Scan in Solitary Thyroid NoduleReport as inadecuate

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Pathology Research InternationalVolume 2011 2011, Article ID 754041, 9 pages

Research Article

Department of Pathology, King Edward Medical University, Lahore 54000, Pakistan

King Edward Medical University, Lahore 54000, Pakistan

Department of Radiology, King Edward Medical University, Lahore 54000, Pakistan

Fatima Jinnah Medical College, Lahore, Pakistan

Received 18 January 2011; Revised 23 February 2011; Accepted 23 February 2011

Academic Editor: Zubair Baloch

Copyright © 2011 Rabia Basharat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. This was a comparative study between FNAC and thyroid scan used to diagnose the solitary thyroid nodule and histopathology was used as gold standard to compare the results of both modalities. We hypothesized that Fine needle aspiration cytology and thyroid scan diagnose solitary thyroid nodule STN as accurately as histopathology. Materials and Methods. This study comprised of 50 patients with solitary thyroid nodules STN presented to OPD. After clinical examination these patients were referred to Centre for Nuclear Medicine, Mayo Hospital Lahore for thyroid function tests and thyroid scan TS. These patients underwent FNAC in the department of Pathology and surgery in Mayo Hospital. The cases were operated and evaluated for histopathological changes. Results. On thyroid scan, 40 patients 80% having cold nodule were labeled as suspicious 10 patients 20% had hot nodule. On FNAC 23 patients 46% had benign lesion, 22 patients 44% had indeterminate lesion and 5 patients 10% had malignant lesions. On histopathology, 45 patients 90% were confirmed to have benign lesions and 5 patients 10%, malignant lesions. After comparison of results of thyroid scan and FNAC with histopathology, the sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of thyroid scan were 80%, 20%, 10%, 90% and 26%, respectively whereas those of FNAC were 80%, 97.7%, 80%, 97.7% and 96%, respectively. Conclusion. Fine needle aspiration was a significantly better predictor of malignancy than thyroid scan and resulted in a smaller proportion of excisions for benign nodules.

Author: Rabia Basharat, Mulazim Hussain Bukhari, Shahzad Saeed, and Tahira Hamid



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