Neuroprotection Offered by Majun Khadar, a Traditional Unani Medicine, during Cerebral Ischemic Damage in RatsReportar como inadecuado

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Evidence-Based Complementary and Alternative MedicineVolume 2011 2011, Article ID 754025, 9 pages

Original Article

Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, New Delhi 110062, India

Brain Research Laboratory, Department of Emergency Medicine, Emory University, Atlanta, Georgia 30322, USA

Received 17 May 2009; Accepted 1 December 2009

Copyright © 2011 Seema Yousuf et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Stroke results in damages to many biochemical, molecular and behavioral deficits. Present study provides evidence of the protective efficacy of a Unani herbal medicine, Majun Khadar MK, against cerebral ischemia-induced behavioral dysfunctions and neurochemical alterations in the hippocampus HIP. Transient focal cerebral ischemia was induced for 2 h followed by reperfusion for 22 h in a rat model. Rats were divided into four groups: sham, middle cerebral artery occluded MCAO, drug sham MK; 0.816 g kg

orally for 15 days and MK pre-treated ischemic group MK + MCAO. Levels of enzymatic and non-enzymatic antioxidants were estimated in HIP along with behavioral testing. MK pre-treatment significantly P < .05–.001 restored the activities of glutathione peroxidase GP×, glutathione reductase GR, glutathione S-transferase GST and decreased the level of lipid peroxidation LPO and H2O2 content in HIP in the MK + MCAO group which were severely altered in the MCAO group. The content of glutathione GSH, total thiols TT and ascorbic acid AsA was significantly depleted in the MCAO group; pretreatment with MK was able to restore its levels. Also in the MK + MCAO group, significant P < .5–.001 recovery in behavioral testing by rota rod and open-field activities was seen as compared with the MCAO group. MK alone did not show any change neither in the status of various antioxidants nor behavioral functions over sham values. Although detailed studies are required for the evaluation of exact neuroprotective mechanism of MK against cerebral ischemia these preliminary experimental findings conclude that MK exhibits neuroprotective effect in cerebral ischemia by potentiating the antioxidant defense system of the brain.

Autor: Seema Yousuf, Fahim Atif, Muzamil Ahmad, Tauheed Ishrat, Badruzzaman Khan, and Fakhrul Islam



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