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Cardiology Research and Practice - Volume 2017 2017, Article ID 7539735, 5 pages -

Review Article

Department of Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, IL 60657, USA

Department of Internal Medicine, Saint Francis Hospital, Evanston, IL 60202, USA

University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA

Correspondence should be addressed to Alvaro Altamirano Ufion

Received 24 January 2017; Revised 25 March 2017; Accepted 19 April 2017; Published 28 May 2017

Academic Editor: Terrence D. Ruddy

Copyright © 2017 Alvaro Altamirano Ufion et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Thyroid hormones play an important role in regulating different metabolism functions and multiple organs’ performance. Changes in the thyroid hormone axis can lead to profound effects on the stability of vital organs and systems, especially the cardiovascular system. Hypothyroidism is classified according to the clinical presentation as overt and subclinical. There is some evidence supporting the benefits of thyroxine hormone replacement for subclinical hypothyroidism on cardiovascular mortality outcomes. However, the clinical relevance of measuring and treating high thyroid-stimulating hormone TSH levels in newly diagnosed heart failure patients with preserved ejection fraction requires further study. In this report, we review the current evidence regarding the prognostic significance of subclinical hypothyroidism in heart failure patients with preserved ejection fraction.

Autor: Alvaro Altamirano Ufion, Beenish Zulfiqar, Abdalla Hassan, Roshanak Habibi, and Prajwal Boddu



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