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Evidence-Based Complementary and Alternative MedicineVolume 2013 2013, Article ID 705121, 17 pages

Review Article

Departamentos de Neuroinmunología, Instituto Nacional de Neurología y Neurocirugía INNN, C.P. 14269, Mexico City, DF, Mexico

Neurobiología Molecular y Celular INNN-UNAM, Instituto Nacional de Neurología y Neurocirugía INNN, C.P. 14269, Mexico City, DF, Mexico

Facultad de Química, Universidad Nacional Autónoma de México UNAM, C.P. 04510, Mexico City, DF, Mexico

Unidad Periferica de NeuroCiencias INNN-UNAM, Instituto Nacional de Neurología y Neurocirugía INNN, C.P. 14269, Mexico City, DF, Mexico

Facultad de Odontología, Universidad Nacional Autónoma de México UNAM, C.P. 04510, Mexico City, DF, Mexico

Neuroquimica, Instituto Nacional de Neurología y Neurocirugía INNN, C.P. 14269, Mexico City, DF, Mexico

Received 25 March 2013; Revised 5 June 2013; Accepted 19 June 2013

Academic Editor: Yew-Min Tzeng

Copyright © 2013 Cristina Trejo-Solís et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Epidemiological studies suggest that including fruits, vegetables, and whole grains in regular dietary intake might prevent and reverse cellular carcinogenesis, reducing the incidence of primary tumours. Bioactive components present in food can simultaneously modulate more than one carcinogenic process, including cancer metabolism, hormonal balance, transcriptional activity, cell-cycle control, apoptosis, inflammation, angiogenesis and metastasis. Some studies have shown an inverse correlation between a diet rich in fruits, vegetables, and carotenoids and a low incidence of different types of cancer. Lycopene, the predominant carotenoid found in tomatoes, exhibits a high antioxidant capacity and has been shown to prevent cancer, as evidenced by clinical trials and studies in cell culture and animal models. In vitro studies have shown that lycopene treatment can selectively arrest cell growth and induce apoptosis in cancer cells without affecting normal cells. In vivo studies have revealed that lycopene treatment inhibits tumour growth in the liver, lung, prostate, breast, and colon. Clinical studies have shown that lycopene protects against prostate cancer. One of the main challenges in cancer prevention is the integration of new molecular findings into clinical practice. Thus, the identification of molecular biomarkers associated with lycopene levels is essential for improving our understanding of the mechanisms underlying its antineoplastic activity.





Autor: Cristina Trejo-Solís, Jose Pedraza-Chaverrí, Mónica Torres-Ramos, Dolores Jiménez-Farfán, Arturo Cruz Salgado, Norma Ser

Fuente: https://www.hindawi.com/



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