Mixed Acinar-Neuroendocrine Carcinoma of the Pancreas with Neuroendocrine PredominanceReport as inadecuate

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Case Reports in MedicineVolume 2013 2013, Article ID 705092, 3 pages

Case Report

Section of GI Cancers and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA

Columbia University Medical Center, New York, NY 10032, USA

Oncology Unit, Third Department of Medicine, Athens University, School of Medicine, Sotiria General Hospital, 115 27 Athens, Greece

Received 5 August 2013; Accepted 19 October 2013

Academic Editor: Yasuhiko Sugawara

Copyright © 2013 Onyekachi Henry Ogbonna et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Pancreatic tumors are rare and could arise from either the exocrine ductal and acinar cells or the endocrine neuroendocrine cells components of the pancreas. In some instances, the occurrence of pancreatic tumors comprising both acinar cells and neuroendocrine cells, with neuroendocrine cells making up more than 30% of the tumor, has been identified. This unique entity has been referred to as mixed acinar-neuroendocrine carcinoma MANEC. Only about 20 such cases have been reported in the literature. Case Report. We report an interesting case of MANEC with neuroendocrine cell predominance in a woman presenting with epigastric pain secondary to a pancreatic mass with acinar and endocrine differentiation. She underwent surgical resection of the tumor and was offered adjuvant treatment chemotherapy with carboplatin, etoposide, and radiotherapy for positive tumor resection margins. Conclusions. Given the paucity of the cases of MANEC, continuous reporting of these cases when identified should be encouraged to aid oncologists in understanding the disease and help establish standardized management.

Author: Onyekachi Henry Ogbonna, Marie Carmel Garcon, Kostas N. Syrigos, and Muhammad Wasif Saif

Source: https://www.hindawi.com/


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