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Computational Intelligence and NeuroscienceVolume 2009 2009, Article ID 658474, 13 pages

Research ArticleChair for Parallel VLSI Systems and Neural Circuits, Dresden University of Technology, 01062 Dresden, Germany

Received 12 June 2008; Revised 31 January 2009; Accepted 11 March 2009

Academic Editor: Rodrigo Quiroga

Copyright © 2009 Christian Mayr et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

When entering a synapse, presynaptic pulse trains are filtered according to the recent pulse history at the synapse and also with respect to their own pulse time course. Various behavioral models have tried to reproduce these complex filtering properties. In particular, the quantal model of neurotransmitter release has been shown to be highlyselective for particular presynaptic pulse patterns. However, since the original, pulse-iterative quantal model does not lend itself to mathematical analysis, investigations have only been carried out via simulations. In contrast, we derive a comprehensive explicit expression for the quantal model. We show the correlation between the parameters of this explicitexpression and the preferred spike train pattern of the synapse. In particular, our analysis of the transmission of modulated pulse trains across a dynamic synapse links the original parameters of the quantal model to the transmission efficacy of two major spiking regimes, that is, bursting and constant-rate ones.





Autor: Christian Mayr, Johannes Partzsch, and Rene Schüffny

Fuente: https://www.hindawi.com/



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