Comparison of viro-immunological marker changes between HIV-1 and HIV-2-infected patients in France.: Comparison between HIV-1 and HIV-2 in FranceReportar como inadecuado




Comparison of viro-immunological marker changes between HIV-1 and HIV-2-infected patients in France.: Comparison between HIV-1 and HIV-2 in France - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

* Corresponding author 1 Biostatistique 2 Epidémiologie, santé publique et développement 3 Hôpital Bichat - Claude Bernard 4 Service de médecine interne et maladies tropicales 5 Hôpital Charles Nicolle

Abstract : BACKGROUND: HIV-2 is known to be less pathogenic than HIV-1, although the underlying mechanisms are still debated. We compared the changes over time in viro-immunological markers in HIV-1 and HIV-2-infected patients living in France during natural history and after initiation of the first combination antiretroviral therapy CART. METHOD: Patients were included in the ANRS CO3 HIV-1 cohort N = 6707 or the ANRS CO5 HIV-2 cohort N = 572. HIV-1-infected patients were matched to HIV-2 patients according to sex, age, HIV transmission group and period of treatment initiation. Changes in markers were estimated using linear mixed models. RESULTS: Analyses were performed for three groups of patients: those with estimated date of contamination 98 HIV-1 and 49 HIV-2-seroincident patients; untreated seroprevalent patients 320 HIV-1 and 160 HIV-2; and those initiating a first CART 59 HIV-1 and 63 HIV-2. In group 1, CD4 T-cell counts decreased less rapidly in HIV-2 than HIV-1 patients -9 versus -49 cells-microl per year, P < 10-4. Results were similar in group 2. Baseline CD4 cell count at CART initiation was not different according to the type of infection. During the first 2 months of treatment, the CD4 cell count increased by +59 cells-microl per month CI 34; 84 for HIV-1 and +24 CI 6; 42 for HIV-2. The plasma viral load drop was threefold more important in HIV-1 patients: -1.56 log10-ml per month versus -0.62 among HIV-2 patients P < 10-4. CONCLUSION: Differences between the two infections during natural history are similar to those previously described in Africa. Once treatment is started, response is poorer in HIV-2 than in HIV-1 patients.

keyword : HIV-1 HIV-2 CD4 CD8 HIV viral load Longitudinal study





Autor: Julia Drylewicz - Sophie Matheron - Estibaliz Lazaro - Florence Damond - Fabrice Bonnet - François Simon - François Dabis - Fra

Fuente: https://hal.archives-ouvertes.fr/



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