Synthesis and Anti-inflammatory Activity of Some Novel 3-6-Substituted-1, 3-benzothiazole-2-yl-2-{4-substituted phenyl amino} methyl quinazolines-4 3H-onesReportar como inadecuado




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E-Journal of Chemistry - Volume 6 2009, Issue 4, Pages 1055-1062

Department of Pharmaceutical Chemistry, V.L. College of Pharmacy, Raichur-584103, Karnataka, India

Received 6 January 2009; Accepted 25 February 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A series of novel 3-6-substituted-1, 3-benzothiazole-2-yl-2-{4-substituted phenyl amino} methyl quinazolines-43H-ones were synthesized by treating 2-chloromethyl-3-6-substituted-1, 3-benzothiazole-2-yl quinazoline-4-3H-one IIa-d with various substituted amine. The compounds IIa-d prepared by treating 2-chloroacetyl amino benzoic acid with different 2-amino-6-substituted benzothiazole. Elemental analysis, IR,

HNMR and mass spectral data confirmed the structure of the newly synthesized compounds. Synthesized quinazolines-4-one derivative were investigated for their anti-inflammatory and antibacterial activity.





Autor: Manish Srivastav, MD. Salahuddin, and S. M. Shantakumar

Fuente: https://www.hindawi.com/



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