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Comparative and Functional Genomics - Volume 2 2001, Issue 2, Pages 80-90

Research Article

Universitätsklinikum Frankfurt, Institut für Biochemie I, Zentrum der Biologischen Chemie, Frankfurt am Main D-60590, Germany

Laboratoire de Biologie Moléculaire et Cellulaire INRA-CNRS, Institute National Agronomique, Thiverval Grignon 78850, France

Universitätsklinikum Frankfurt, Institut für Biochemie I, Zentrum der Biologischen Chemie, Theodor-Stern-Kai 7, Haus 25 B, Frankfurt am Main D-60590, Germany

Technische Universität München, Institut für Tierzucht und Molekulare Genetik, Freising-Weihenstephan D-85350, Germany

Received 3 January 2001; Accepted 10 February 2001

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We here report the complete nucleotide sequence of the 47.9 kb mitochondrial mt genomefrom the obligate aerobic yeast Yarrowia lipolytica. It encodes, all on the same strand,seven subunits of NADH: ubiquinone oxidoreductase ND1-6, ND4L, apocytochromeb COB, three subunits of cytochrome oxidase COX1, 2, 3, three subunits of ATPsynthetase ATP6, 8 and 9, small and large ribosomal RNAs and an incomplete set oftRNAs. The Y. lipolytica mt genome is very similar to the Hansenula wingei mt genome,as judged from blocks of conserved gene order and from sequence homology. The extraDNA in the Y. lipolytica mt genome consists of 17 group 1 introns and stretches of A+Trichsequence, interspersed with potentially transposable GC clusters. The usual mould mtgenetic code is used. Interestingly, there is no tRNA able to read CGN arginine codons.CGN codons could not be found in exonic open reading frames, whereas they do occur inintronic open reading frames. However, several of the intronic open reading frames haveaccumulated mutations and must be regarded as pseudogenes. We propose that this mayhave been triggered by the presence of untranslatable CGN codons. This sequence isavailable under EMBL Accession No. AJ307410.





Autor: Stefan Kerscher, Gregor Durstewitz, Serge Casaregola, Claude Gaillardin, and Ulrich Brandt

Fuente: https://www.hindawi.com/



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