Correlation between Serum Levels of High Mobility Group Box-1 Protein and Pancreatitis: A Meta-AnalysisReportar como inadecuado

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BioMed Research International - Volume 2015 2015, Article ID 430185, 10 pages -

Review Article

Department of Gastroenterology, Shengjing Hospital, China Medical University, Sanhao Street No. 36, Heping District, Shenyang 110001, China

Department of Oncology, Renji Hospital, Shanghai Jiao Tong University, Shanghai 200000, China

Received 17 July 2014; Accepted 30 October 2014

Academic Editor: Bo Zuo

Copyright © 2015 Yan Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Aberrant expression of high mobility group box-1 protein HMGB1 contributes to the progression of various inflammatory diseases. This meta-analysis focused on the clinical significance of serum HMGB1 levels in pancreatitis patients, with the goal of building a novel diagnostic score model. Method. We conducted a meta-analysis by searching in the PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine CBM, and China National Knowledge Infrastructure CNKI databases without any language restrictions. Studies were pooled and standard mean difference SMD and its corresponding 95% confidence intervals 95% CIs were calculated. Version 12.0 STATA software was used for statistical analysis. Results. We performed a final analysis of 841 subjects from 12 clinical case-control studies. The meta-analysis results showed a positive association between serum HMGB1 levels and the progression of pancreatitis. In the subgroup analysis by country, high serum level of HMGB1 may be related to pancreatitis progression in China, Korea, Hungary, and Japan populations all . Conclusion. The present meta-analysis indicated that serum HMGB1 level was statistically elevated in patients with pancreatitis, and thus serum levels of HMGB1 could be determined to be a useful biomarker for pancreatitis patients.

Autor: Yan Lin, Lian-Jie Lin, Yu Jin, Yong Cao, Ying Zhang, Chang-Qing Zheng, Jia-Li Liu, and Sheng-Li Yang



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