Factors associated with severity of occupational asthma with a latency period at diagnosis.Reportar como inadecuado




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* Corresponding author 1 Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé 2 Service de la Santé au Travail Poincaré 3 Institut Interuniversitaire de Médecine du Travail de Paris Ile-de-France 4 Service de pathologie professionnelle 5 Service de la Santé au Travail Fernand Widal 6 Unité de pathologie professionnelle

Abstract : BACKGROUND: Severity of occupational asthma at diagnosis is an important prognostic factor. The aim of this study was to determine which factors affect the severity of occupational asthma with a latency period at diagnosis. METHODS: The study population consisted of 229 consecutive subjects with occupational asthma with a latency period recruited by four occupational health departments and divided into two groups according to the severity of the disease at diagnosis. The moderate-severe FEV1 300 microg, n = 128 groups were compared in terms of clinical and demographic parameters. Multivariate analysis using logistic regressions was performed to examine factors associated with asthma severity. RESULTS: Duration of symptoms before diagnosis was significantly longer in the moderate-severe group mean +- SD: 6.3 +- 6.8 years vs 3.4 +- 4.4 years, P < 0.001. Sex ratio, age, atopy, smoking habits, duration of exposure before symptoms, and molecular weight of the causal agent were not significantly different between the two groups. On multivariate analysis, only duration of symptoms before diagnosis was associated with asthma severity aOR = 1.12, 95% CI 1.05-1.18, P < 0.001. CONCLUSIONS: Severity of occupational asthma with a latency period at diagnosis was associated with duration of symptoms before diagnosis, but not with the type of causal agent. This finding emphasizes the need for early diagnosis and avoidance of exposure.





Autor: Alexis Descatha - Hélène Leproust - Dominique Choudat - Robert Garnier - Jean-Claude Pairon - Jacques Ameille -

Fuente: https://hal.archives-ouvertes.fr/



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