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BioMed Research International - Volume 2014 2014, Article ID 162314, 8 pages -

Research ArticleSchool of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India

Received 4 December 2013; Revised 8 January 2014; Accepted 14 January 2014; Published 19 February 2014

Academic Editor: Emilia Lecuona

Copyright © 2014 Munazah Fazal Qureshi and Sushil K. Jha. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Increased bodily CO2 concentration alters cellular pH as well as sleep. The proton pump, which plays an important role in the homeostatic regulation of cellular pH, therefore, may modulate sleep. We investigated the effects of the proton pump inhibitor “lansoprazole” on sleep-wakefulness. Male Wistar rats were surgically prepared for chronic polysomnographic recordings. Two different doses of lansoprazole low: 1 mg-kg; high: 10 mg-kg were injected intraperitoneally in the same animal and sleep-wakefulness was recorded for 6 hrs. The changes in sleep-wakefulness were compared statistically. Percent REM sleep amount in the vehicle and lansoprazole low dose groups was and , respectively, which increased significantly in the lansoprazole high dose group by 31.75% from vehicle and 34.21% from low dose. Also, REM sleep episode numbers significantly increased in lansoprazole high dose group. Further, the sodium-hydrogen exchanger blocker “amiloride” 10 mg-kg; i.p. did not alter sleep-wake architecture. Our results suggest that the proton pump plays an important role in REM sleep modulation and supports our view that REM sleep might act as a sentinel to help maintain normal CO2 level for unperturbed sleep.

Autor: Munazah Fazal Qureshi and Sushil K. Jha



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