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ISRN ImmunologyVolume 2013 2013, Article ID 865671, 7 pages

Research ArticleGamaleya Research Institute for Epidemiology and Microbiology, Russian Ministry of Health, Gamaleya Street 18, Moscow 123098, Russia

Received 29 March 2013; Accepted 8 May 2013

Academic Editors: A. Boon and P. Puccetti

Copyright © 2013 N. V. Kobets et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


It was previously demonstrated that mice of I-StSnEgYCit I-St strain are more susceptible to tuberculosis infection than A-SnYCit A-Sn mice, and this susceptibility was controlled by a few interacting QTLs mapped to chromosomes 3, 9, 17. It was also shown, that I-St mice displayed higher susceptibility to acute salmonella disease after intraperitoneal challenge with S. enterica serovar Typhimurium. Genetic mapping showed the involvement of Tbs2 D9Mit89 loci in control of both salmonella and tuberculosis infections. In this study we define the immunological correlates of susceptibility in I-St mice after oral administration of S. enterica serovar Typhimurium. We found that resistance-susceptibility in I-St and A-Sn mice in our experiments correlated with differential pattern of early local and systemic responses of innate cells and specifically with higher involvement of Gr-1

cells in local responses of resistant mice. This correlated with higher mucosal antibody production in A-Sn mice compared to I-St. I-St mice had predominant local involvement of CD11c

cells and lack of mucosal antibodies. CD11c

cells were the major type of cells that facilitated dissemination of salmonella to the target organs, while Gr-1

cells contributed to exaggerated systemic inflammatory responses later in the course of infection. Our observations regarding the role of different cell populations in local and systemic immunity in susceptible and resistant mice are of importance for understanding of salmonella-induced cellular pathology and development of the strategy of its control.

Autor: N. V. Kobets, L. N. Nesterenko, and D. V. Balunets

Fuente: https://www.hindawi.com/


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