Antinociceptive Effect of Tephrosia sinapou Extract in the Acetic Acid, Phenyl-p-benzoquinone, Formalin, and Complete Freund’s Adjuvant Models of Overt Pain-Like Behavior in MiceReportar como inadecuado




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Scientifica - Volume 2016 2016, Article ID 8656397, 8 pages -

Research Article

Department of Pharmaceutical Sciences, Health Science Centre, University Hospital, Londrina State University, Londrina, PR, Brazil

Departamento de Patologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, PR, Brazil

Universidade Tecnológica Federal do Paraná, Londrina, PR, Brazil

Laboratório de Pesquisa em Moléculas Bioativas, Departamento de Química, Universidade Estadual de Londrina, Londrina, PR, Brazil

Received 28 December 2015; Revised 13 April 2016; Accepted 21 April 2016

Academic Editor: Jesper Mogensen

Copyright © 2016 Renata M. Martinez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tephrosia toxicaria, which is currently known as Tephrosia sinapou Buc’hoz A. Chev. Fabaceae, is a source of compounds such as flavonoids. T. sinapou has been used in Amazonian countries traditional medicine to alleviate pain and inflammation. The purpose of this study was to evaluate the analgesic effects of T. sinapou ethyl acetate extract in overt pain-like behavior models in mice by using writhing response and flinching-licking tests. We demonstrated in this study that T. sinapou extract inhibited, in a dose 1–100 mg-kg dependent manner, acetic acid- and phenyl-p-benzoquinone- PBQ- induced writhing response. Furthermore, it was active via intraperitoneal, subcutaneous, and peroral routes of administration. T. sinapou extract also inhibited formalin- and complete Freund’s adjuvant- CFA- induced flinching-licking at 100 mg-kg dose. In conclusion, these findings demonstrate that T. sinapou ethyl acetate extract reduces inflammatory pain in the acetic acid, PBQ, formalin, and CFA models of overt pain-like behavior. Therefore, the potential of analgesic activity of T. sinapou indicates that it deserves further investigation.





Autor: Renata M. Martinez, Ana C. Zarpelon, Talita P. Domiciano, Sandra R. Georgetti, Marcela M. Baracat, Isabel C. Moreira, Cesar

Fuente: https://www.hindawi.com/



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