COMT but not serotonin-related genes modulates the influence of childhood abuse on anger traits.Reportar como inadecuado

COMT but not serotonin-related genes modulates the influence of childhood abuse on anger traits. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

* Corresponding author 1 Département de Psychiatrie 2 McGill Group for Suicide Studies 3 Neuropsychiatrie : recherche épidémiologique et clinique 4 Service de Psychologie Médicale et Psychiatrie 5 IMRB - Institut Mondor de recherche biomédicale 6 Département Hospitalo-Universitaire de Psychiatrie 7 Department of Medical and Molecular Genetics 8 Département de médecine génétique et développement

Abstract : Anger-related traits are regulated by genes as well as early environmental factors. Both childhood maltreatment and genes underlie vulnerability to suicidal behaviors, possibly by affecting the constitution of intermediate phenotypes such as anger traits. The aim of this study was to test the interaction between nine candidate genes and childhood maltreatment in modulating anger-related traits in 875 adult suicide attempters. The State-Trait Anger Expression Inventory and the Childhood Trauma Questionnaire were used to examine anger traits and traumatic childhood experiences, respectively. The functional polymorphism of the catecholamine-O-methyl-transferase COMT gene Val158Met significantly modulated the association between sexual abuse and anger-trait level P = 0.001. In the presence of sexual abuse, individuals carrying the Val high-activity allele displayed greater disposition toward anger than individuals homozygous for the Met allele P = 0.0003. Notably, none of the serotonin-related genes influenced the effect of childhood abuse on anger traits. The results of the present study suggest that anger-trait level is influenced by the interaction between childhood abuse and functional polymorphism in the COMT gene. This study was carried out in a population with a high frequency of childhood abuse and a high disposition toward anger, and replication in healthy subjects is needed.

Keywords : comt serotonin genes trait anger suicidal behaviors sexual abuse

Autor: Nader Perroud - Isabelle Jaussent - Sébastien Guillaume - Frank Bellivier - Patrick Baud - Fabrice Jollant - Marion Leboyer - Ca



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