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Mediators of InflammationVolume 2010 2010, Article ID 865601, 9 pages

Review ArticleCellerix S.A, Parque Tecnológico de Madrid, Calle Marconi 1, Tres Cantos, 28760 Madrid, Spain

Received 19 January 2010; Accepted 14 April 2010

Academic Editor: Andrew Parker

Copyright © 2010 Olga DelaRosa and Eleuterio Lombardo. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mesenchymal stem cells MSCs are of special interest as therapeutic agents in the settings of both chronic inflammatory and autoimmune diseases. Toll-like receptors TLR ligands have been linked with the perpetuation of inflammation in a number of chronic inflammatory diseases due to the permanent exposure of the immune system to TLR-specific stimuli. Therefore, MSCs employed in therapy can be potentially exposed to TLR ligands, which may modulate MSC therapeutic potential in vivo. Recent results demonstrate that MSCs are activated by TLR ligands leading to modulation of the differentiation, migration, proliferation, survival, and immunosuppression capacities. However inconsistent results among authors have been reported suggesting that the source of MSCs, TLR stimuli employed or culture conditions play a role. Notably, activation by TLR ligands has not been reported to modulate the “immunoprivileged” phenotype of MSCs which is of special relevance regarding the use of allogeneic MSC-based therapies. In this review, we discuss the available data on the modulation of MSCs activity through TLR signalling.





Autor: Olga DelaRosa and Eleuterio Lombardo

Fuente: https://www.hindawi.com/



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