Synthesis and Biological Evaluation of Substituted Thiophenyl Derivatives of Indane-1, 3-DioneReportar como inadecuado




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E-Journal of Chemistry - Volume 4 2007, Issue 3, Pages 428-433

K. M. College of Pharmacy, Madurai, Tamilnadu, India

Received 18 January 2007; Accepted 2 March 2007

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Indane-1, 3-dione 1 synthesized by condensation of diethyl phthalate and ethyl acetate in presence of sodium ethoxide gave sodium salt of ester derivative, which on neutralization in presence of sulphuric acid afford 1. Various thiols where converted to their respective disulphide 3 which on treatment with 1 gave 2-substituted thio phenyl derivatives 4a-g of 1. The synthesized compounds were characterized on the basis of I.R and H

NMR. Synthesized compounds 4a-g were investigated for their anticoagulant, analgesic, anti-inflammatory, antifungal, antibacterial and anticancer activities. Some of the synthesized compounds have shown moderate activities.





Autor: D. Giles, M. S. Prakash, and K. V. Ramseshu

Fuente: https://www.hindawi.com/



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