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Case Reports in PathologyVolume 2014 2014, Article ID 865453, 3 pages

Case Report

Department of Emergency Medicine, Tehran University of Medical Sciences, Tehran, Iran

Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

Dr. Daneshbod Pathology Laboratory, Department of Pathology, Shiraz, Iran

Received 19 October 2013; Accepted 23 December 2013; Published 26 March 2014

Academic Editors: A. Rajput and S. Shousha

Copyright © 2014 Hadi Mirfazaelian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Spontaneous rupture of spleen due to malignant melanoma is a rare situation, with only a few case reports in the literature. This study reports a previously healthy, 30-year-old man who came with chief complaint of acute abdominal pain to emergency room. On physical examination, abdominal tenderness and guarding were detected to be coincident with hypotension. Ultrasonography revealed mild splenomegaly with moderate free fluid in abdominopelvic cavity. Considering acute abdominal pain and hemodynamic instability, he underwent splenectomy with splenic rupture as the source of bleeding. Histologic examination showed diffuse infiltration by tumor. Immunohistochemical study positive for S100, HMB45, and vimentin and negative for CK, CD10, CK20, CK7, CD30, LCA, EMA, and chromogranin confirmed metastatic malignant melanoma. On further questioning, there was a past history of a nasal dark skin lesion which was removed two years ago with no pathologic examination. Spontaneous nontraumatic rupture of spleen is an uncommon situation and it happens very rarely due to neoplastic metastasis. Metastasis of malignant melanoma is one of the rare causes of the spontaneous rupture of spleen.

Autor: Hadi Mirfazaelian, Ahmad Oryan, Aida Davari, Khosrow Daneshbod, and Yahya Daneshbod

Fuente: https://www.hindawi.com/


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