Synthesis and Spectroscopic Characterization of Some New Axially Ligated IndiumIII Macrocyclic Complexes and Their Biological ActivitiesReport as inadecuate




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Bioinorganic Chemistry and ApplicationsVolume 2014 2014, Article ID 865407, 7 pages

Research Article P.G. Department of Chemistry, University of Jammu, Jammu and Kashmir 180006, India

Received 30 May 2014; Accepted 6 July 2014; Published 21 July 2014

Academic Editor: Luigi Marzilli

Copyright © 2014 Gauri D. Bajju et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The synthesis and spectroscopic characterization of new axially ligated indiumIII porphyrin complexes were reported. ChloroindiumIII porphyrin TPPIn-Cl was obtained in good yield by treating the corresponding free base with indium trichloride. The action of the different phenols on chloroderivatives TPPIn-Cl led to the corresponding phenolato complexes TPPIn-X. These derivatives were characterized on the basis of mass spectrometry,

H-NMR, IR, and UV-visible data. The separation and isolation of these derivatives have been achieved through chromatography. The spectral properties of free base porphyrin and its corresponding metallated and axially ligated indiumIII porphyrin compounds were compared with each other. A detailed analysis of UV-Vis,

H-NMR, and IR suggested the transformation from free base porphyrin to indiumIII porphyrin. Besides,

C-NMR and fluorescence spectra were also reported and interpreted. The stability of these derivatives has also been studied through thermogravimetry. The complexes were also screened for anticancerous activities. Among all the complexes, 4-MePhO-InTPP shows highest anticancerous activity. The title complexe, TPPIn-X where X = different phenolates, represents a five-coordinate indiumIII porphyrin complex in a square-pyramidal geometry with the phenolate anion as the axial ligand.





Author: Gauri D. Bajju, Altaf Ahmed, Deepmala Gupta, Ashu Kapahi, and Gita Devi

Source: https://www.hindawi.com/



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