Effect of Fluticasone and Salmeterol on Tracheal Responsiveness to Ovalbumin and Lung Inflammation, Administrated during and after SensitizationReportar como inadecuado




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The Scientific World Journal - Volume 2014 2014, Article ID 865292, 8 pages -

Research Article

Neurogenic Inflammation Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran

Department of Biology, Faculty of Sciences, Kerman University of Shahid Bahonar, Kerman 9177948564, Iran

Received 31 August 2013; Accepted 12 November 2013; Published 19 January 2014

Academic Editors: J.-Y. Shih and F. Varoli

Copyright © 2014 Zahra Gholamnezhad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The effect of duration of administration of fluticasone propionate and salmeterol on tracheal responsiveness to ovalbumin and total and differential white blood cell in sensitized guinea pig was examined. Six groups of guinea pigs were sensitized to ovalbumin. Three groups of them were subjected to inhaled fluticasone propionate and salmeterol, one group during sensitization A, one group after that for 18 days, B, and the other one during sensitization but with 18 days delay before measurements C. Three other groups were treated with placebo in the same manner. The tracheal responsiveness to ovalbumin and total and differential white blood cells of three placebo groups were significantly higher than those of control group for all cases. Tracheal responsiveness to ovalbumin and total and differential white blood cell in treated groups with fluticasone propionate and salmeterol were significantly decreased compared to those of placebo groups nonsignificant to . The improvement in all variables in treatment groups A and C were more pronounced than group B. The results showed that fluticasone propionate and salmeterol had a prevention effect on tracheal hyperresponsiveness to ovalbumin and lung inflammation which was more pronounced when administered during than after sensitization.





Autor: Zahra Gholamnezhad, Mohammad Hossain Boskabady, Mohammad Reza Khazdair, Mahmoud Hosseini, and Mahdi Abbasnejad

Fuente: https://www.hindawi.com/



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