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BioMed Research InternationalVolume 2014 2014, Article ID 865270, 5 pages

Review ArticleDepartment of Pathology and Laboratory Medicine, and Orthopedic Hospital Research Center, University of California, David Geffen School of Medicine, UCLA, 10833 Le Conte Avenue, A3-251 CHS, Los Angeles, CA 90095, USA

Received 23 January 2014; Accepted 9 March 2014; Published 6 April 2014

Academic Editor: Benjamin Levi

Copyright © 2014 Marco Mravic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The development of tissue engineering and regeneration constitutes a new platform for translational medical research. Effective therapies for bone engineering typically employ the coordinated manipulation of cells, biologically active signaling molecules, and biomimetic, biodegradable scaffolds. Bone tissue engineering has become increasingly dependent on the merging of innovations from each of these fields, as they continue to evolve independently. This foreword will highlight some of the most recent advances in bone tissue engineering and regeneration, emphasizing the interconnected fields of stem cell biology, cell signaling biology, and biomaterial research. These include, for example, novel methods for mesenchymal stem cell purification, new methods of Wnt signaling pathway manipulation, and cutting edge computer assisted nanoscale design of bone scaffold materials. In the followingspecial issue, we sought to incorporate these diverse areas of emphasis in order to reflect current trends in the field.

Author: Marco Mravic, Bruno Péault, and Aaron W. James



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