Preparation and Characterization of a Novel Hybrid Hydrogel Composed of Bombyx mori Fibroin and PolyN-isopropylacrylamideReportar como inadecuado

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Journal of NanomaterialsVolume 2013 2013, Article ID 832710, 9 pages

Research ArticleInstitute of Ecology and Environment, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu 610065, China

Received 18 September 2012; Accepted 22 November 2012

Academic Editor: Lian Gao

Copyright © 2013 Ting Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A novel hybrid hydrogel was prepared and investigated based on silkworm silk fibroin and polyN-isopropylacrylamide PNIPAAm. PNIPAAm was introduced to silk fibroin, the resultant composite hydrogel was examined, and freeze-dried SF-PNIPAAm scaffold was analyzed using LB-550 dynamic light scattering particle-size analyzer, circular dichroism CD, and scanning electron microscopy SEM. Our results suggested that the hybrid hydrogels owned the porous sponge-like structures, and the gelation time of SF-PNIPAAm hybrids decreased with an increase in temperature and concentration of each polymer. Results of rheological analysis suggested that the rheological property of resultant SF-PNIPAAm gel depended on the concentration combinations as well as the aging time, which elapsed after mixing the two polymers. Results of CD spectra demonstrated that pH showed little influence on the secondary structure of silk fibroin, and significant changes of , , and G* as surrounding increase temperature above the lower critical solution temperature LCST.

Autor: Ting Wang, Ling-lei Zhang, and Xiao-jia He



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