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Neural Plasticity - Volume 2015 2015, Article ID 830871, 22 pages -

Review ArticleThe Unit for Cognitive Neuroscience, Department of Psychology, University of Copenhagen, Oester Farimagsgade 2A, 1354 Copenhagen K, Denmark

Received 9 February 2015; Accepted 9 June 2015

Academic Editor: Midori A. Yenari

Copyright © 2015 Elise Wogensen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The objective of the present paper is to review the current status of exercise as a tool to promote cognitive rehabilitation after acquired brain injury ABI in animal model-based research. Searches were conducted on the PubMed, Scopus, and psycINFO databases in February 2014. Search strings used were: exercise and animal model or rodent or rat and traumatic brain injury or cerebral ischemia or brain irradiation. Studies were selected if they were 1 in English, 2 used adult animals subjected to acquired brain injury, 3 used exercise as an intervention tool after inflicted injury, 4 used exercise paradigms demanding movement of all extremities, 5 had exercise intervention effects that could be distinguished from other potential intervention effects, and 6 contained at least one measure of cognitive and-or emotional function. Out of 2308 hits, 22 publications fulfilled the criteria. The studies were examined relative to cognitive effects associated with three themes: exercise type forced or voluntary, timing of exercise early or late, and dose-related factors intensity, duration, etc

The studies indicate that exercise in many cases can promote cognitive recovery after brain injury. However, the optimal parameters to ensure cognitive rehabilitation efficacy still elude us, due to considerable methodological variations between studies.

Author: Elise Wogensen, Hana Malá, and Jesper Mogensen



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