The Prevalence of Helicobacter pylori Virulence Factors in Bhutan, Vietnam, and Myanmar Is Related to Gastric Cancer IncidenceReport as inadecuate




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BioMed Research International - Volume 2015 2015, Article ID 830813, 8 pages -

Research Article

Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan

Department of Molecular Biology, 108 Hospital, Hanoi, Vietnam

Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh, Vietnam

Gastroenterology Unit, Department of Medicine, Thammasat University Hospital, Pathum Thani 12120, Thailand

GI and Liver Center, Bangkok Medical Center, Bangkok 10310, Thailand

Department of Surgery, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan

Department of Molecular Pathology, Oita University Faculty of Medicine, Yufu 897-5593, Japan

Department of Gastroenterology, Oita University Faculty of Medicine, Yufu 879-5593, Japan

Department of Gastroenterology, Yangon General Hospital, Yangon 11131, Myanmar

Department of Gastroenterology, 108 Hospital, Hanoi, Vietnam

Department of Medicine-Gastroenterology, Baylor College of Medicine and Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA

Received 4 December 2014; Revised 26 January 2015; Accepted 31 January 2015

Academic Editor: Mikihiro Fujiya

Copyright © 2015 Tran Thi Huyen Trang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Gastric cancer is a significant health problem in Asia. Although the prevalence of Helicobacter pylori infection is similar in Bhutan, Vietnam, and Myanmar, the incidence of gastric cancer is highest in Bhutan, followed by Vietnam and Myanmar. We hypothesized that H. pylori virulence factors contribute to the differences. The status of cagA, vacA, jhp0562, and β-1,3galTjhp0563 was examined in 371 H. pylori-infected patients from Bhutan, Vietnam, and Myanmar. Each virulence factor could not explain the difference of the incidence of gastric cancer. However, the prevalence of quadruple-positive for cagA, vacA s1, vacA m1, and jhp0562-positive-β-1,3galT-negative was significantly higher in Bhutan than in Vietnam and Myanmar and correlated with gastric cancer incidence. Moreover, gastritis-staging scores measured by histology of gastric mucosa were significantly higher in quadruple-positive strains. We suggest that the cagA, vacA s1, vacA m1, and jhp0562-positive-β-1,3galT-negative genotype may play a role in the development of gastric cancer.





Author: Tran Thi Huyen Trang, Seiji Shiota, Miyuki Matsuda, Tran Thanh Binh, Rumiko Suzuki, Ratha-korn Vilaichone, Varocha Mahachai,

Source: https://www.hindawi.com/



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