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The Scientific World Journal - Volume 2014 2014, Article ID 830649, 7 pages -

Clinical Study

Department of Internal Medicine, University of Catania, Via Santa Sofia 78, 95100 Catania, Italy

Department of Geriatrics, Garibaldi Hospital, 95100 Catania, Italy

Nephrology and Dialysis Unit, “San Giovanni di Dio” Hospital, 92100 Agrigento, Italy

Department of Scienze della Senescenza, University of Catania, 95100 Catania, Italy

Received 25 July 2014; Revised 12 November 2014; Accepted 17 November 2014; Published 4 December 2014

Academic Editor: Anja Verhulst

Copyright © 2014 Luca Zanoli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We evaluated in elderly subjects a the ability of GFR formulas to discriminate chronic kidney disease CKD, b the correlation between renal morphology and function, and c the usefulness of combined r-US and GFR formulas to detect CKD. A total of 72 patients were enrolled mean age 80 ± 7 years, male sex 44%, serum creatinine 0.98 ± 0.42 mg-dL, and CKD 57%. Cockcroft-Gault showed the highest sensitivity 78% and specificity 94% for CKD and was correlated with kidney volume , . All formulas failed to provide a reliable estimate of GFR. In multivariate analysis, Cockcroft-Gault < 52 mL-min and kidney sinus section area < 28 cm

showed the highest accuracy for the identification of CKD subjects AUC 0.90, . MDRD and CKD-EPI differed significantly for GFR ≥90 mL-min. Conclusions. Cockcroft-Gault < 52 mL-min was able to discriminate subjects with CKD but all formulas failed to provide a reliable estimate of GFR. The combined use of r-US and Cockcroft-Gault formula improved the ability to discriminate CKD in elderly subjects.

Autor: Luca Zanoli, Giulia Romano, Marcello Romano, Stefania Rastelli, Francesco Rapisarda, Antonio Granata, Pasquale Fatuzzo, Mar



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