Antiproliferative Effects of Honey and of Its Polyphenols: A ReviewReport as inadecuate

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Journal of Biomedicine and BiotechnologyVolume 2009 2009, Article ID 830616, 13 pages

Review ArticleSchool of Medical Science and Technology, Indian Institute of Technology, West-Bengal, Kharagpur 721 302, India

Received 5 February 2009; Revised 16 April 2009; Accepted 13 May 2009

Academic Editor: Kapil Mehta

Copyright © 2009 Saravana Kumar Jaganathan and Mahitosh Mandal. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Honey has been used since long time both in medical and domestic needs, but only recently the antioxidant property of it came to limelight. The fact that antioxidants have several preventative effects against different diseases, such as cancer, coronary diseases, inflammatory disorders, neurological degeneration, and aging, led to search for food rich in antioxidants. Chemoprevention uses various dietary agents rich in phytochemicals which serve as antioxidants. With increasing demand for antioxidant supply in the food, honey had gained vitality since it is rich in phenolic compounds and other antioxidants like ascorbic acid, amino acids, and proteins. Some simple and polyphenols found in honey, namely, caffeic acid CA, caffeic acid phenyl esters CAPE, Chrysin CR, Galangin GA, Quercetin QU, Kaempferol KP, Acacetin AC, Pinocembrin PC, Pinobanksin PB, and Apigenin AP, have evolved as promising pharmacological agents in treatment of cancer. In this review, we reviewed the antiproliferative and molecular mechanisms of honey and above-mentioned polyphenols in various cancer cell lines.

Author: Saravana Kumar Jaganathan and Mahitosh Mandal



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