Cortical localization of maternal embryonic leucine zipper kinase MELK implicated in cytokinesis in early xenopus embryos.Reportar como inadecuado




Cortical localization of maternal embryonic leucine zipper kinase MELK implicated in cytokinesis in early xenopus embryos. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

* Corresponding author 1 IGDR - Institut de Génétique et Développement de Rennes

Abstract : MELK has been implicated in a large variety of functions. Because its level is elevated in cancer tissues and it is involved in cell proliferation, MELK is considered as a potential therapeutic target for cancers. In a recent, study we have shown that MELK is involved in cytokinesis in early Xenopus laevis embryos. MELK dynamically accumulates at the cell cortex including a narrow band corresponding to the presumptive division furrow shortly before cytokinesis onset. MELK co-localizes and interacts with anillin an important regulator of cytokinesis. In addition, MELK overexpression interferes with accumulation at the cleavage furrow of activated Rho GTPase another crucial regulator of cytokinesis. Interestingly, our study also revealed that a transition implying a change in the direction of asymmetric furrow ingression occurs during early development. After this transition, MELK, as well as other proteins involved in cytokinesis, do not localize anymore as a band at the equatorial cortex but still localizes at the cell cortex. Our results indicate that cortical localization is an important feature of MELK in X. laevis embryos.

Keywords : cytokinesis mitosis cell cortex anillin RhoA asymmetric furrowing xenopus





Autor: Jean-Pierre Tassan -

Fuente: https://hal.archives-ouvertes.fr/



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