Watermelon Citrullus lanatus Thunb. Matsum. and Nakai Juice Modulates Oxidative Damage Induced by Low Dose X-Ray in MiceReportar como inadecuado




Watermelon Citrullus lanatus Thunb. Matsum. and Nakai Juice Modulates Oxidative Damage Induced by Low Dose X-Ray in Mice - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BioMed Research International - Volume 2014 2014, Article ID 512834, 6 pages -

Research Article

Department of Medical Laboratory Technology, Faculty of Health Sciences, Universiti Teknologi MARA, UiTM Puncak Alam, 42300 Bandar Puncak Alam, Selangor, Malaysia

Department of Medical Imaging, Faculty of Health Sciences, Universiti Teknologi MARA, UiTM Puncak Alam, 42300 Bandar Puncak Alam, Selangor, Selangor, Malaysia

Received 20 February 2014; Revised 8 April 2014; Accepted 8 April 2014; Published 29 April 2014

Academic Editor: José Carlos Tavares Carvalho

Copyright © 2014 Mohd Khairul Amran Mohammad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Watermelon is a natural product that contains high level of antioxidants and may prevent oxidative damage in tissues due to free radical generation following an exposure to ionizing radiation. The present study aimed to investigate the radioprotective effects of watermelon Citrullus lanatus Thunb. Matsum. and Nakai juice against oxidative damage induced by low dose X-ray exposure in mice. Twelve adult male ICR mice were randomly divided into two groups consisting of radiation Rx and supplementation Tx groups. Rx received filtered tap water, while Tx was supplemented with 50% v-v watermelon juice for 28 days ad libitum prior to total body irradiation by 100 μGy X-ray on day 29. Brain, lung, and liver tissues were assessed for the levels of malondialdehyde MDA, apurinic-apyrimidinic AP sites, glutathione GSH, and superoxide dismutase SOD inhibition activities. Results showed significant reduction of MDA levels and AP sites formation of Tx compared to Rx . Mice supplemented with 50% watermelon juice restore the intracellular antioxidant activities by significantly increased SOD inhibition activities and GSH levels compared to Rx. These findings may postulate that supplementation of 50% watermelon Citrullus lanatus Thunb. Matsum. and Nakai juice could modulate oxidative damage induced by low dose X-ray exposure.





Autor: Mohd Khairul Amran Mohammad, Muhamad Idham Mohamed, Ainul Mardhiyah Zakaria, Hairil Rashmizal Abdul Razak, and Wan Mazlina Md.

Fuente: https://www.hindawi.com/



DESCARGAR PDF




Documentos relacionados