Familial Aggregation of Metabolic Syndrome Indicators in Portuguese FamiliesReport as inadecuate

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1 CIFI²D 2 Louisiana State University Baton Rouge 3 ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition

Abstract : Background and Aims. Family studies are well suited to investigate the genetic architecture underlying the metabolic syndrome MetS. The purposes of this paper were i to estimate heritabilities for each of the MetS indicators, and ii to test the significance of familial intratrait and cross-trait correlations in MetS markers. Methods and Results. This study included 1,363 individuals from 515 Portuguese families in which five MetS components, including waist circumference WC, blood pressure BP, HDL-cholesterol, triglycerides TG, and glucose GLU, were measured. Intratrait and cross-trait familial correlations of these five components were estimated using Generalized Estimating Equations. Each MetS component was significantly heritable ℎ 2 ranged from 0.12 to 0.60 and exhibited strong familial resemblance with correlations between biological relatives of similar magnitude to those observed between spouses. With respect to cross-trait correlations, familial resemblance was very weak except for the HDL-TG pair. Conclusions. The present findings confirm the idea of familial aggregation in MetS traits. Spousal correlations were, in general, of the same magnitude as the biological relatives- correlations suggesting that most of the phenotypic variance in MetS traits could be explained by shared environment.

Author: D. M. Santos - P. T. Katzmarzyk - D.-A. Trégouet - T. N. Gomes - F. K. Santos - J. A. Maia -

Source: https://hal.archives-ouvertes.fr/


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