Significant reduction of antibiotic use in the community after a nationwide campaign in France, 2002-2007.Report as inadecuate

Significant reduction of antibiotic use in the community after a nationwide campaign in France, 2002-2007. - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 Pharmacoepidemiologie et Evaluation de l-Impact des Produits de Sante Sur les Populations 2 Pharmacoépidémiologie et maladies infectieuses 3 Caisse Nationale d-Assurance Maladie des Travailleurs Salariés 4 Régime Social des Indépendants 5 ESIM - Epidémiologie des maladies infectieuses et modélisation 6 Service de Médecine Aiguë Spécialisée

Abstract : BACKGROUND: Overuse of antibiotics is the main force driving the emergence and dissemination of bacterial resistance in the community. France consumes more antibiotics and has the highest rate of beta-lactam resistance in Streptococcus pneumoniae than any other European country. In 2001, the government initiated -Keep Antibiotics Working-; the program-s main component was a campaign entitled -Les antibiotiques c-est pas automatique-Antibiotics are not automatic- launched in 2002. We report the evaluation of this campaign by analyzing the evolution of outpatient antibiotic use in France 2000-2007, according to therapeutic class and geographic and age-group patterns. METHODS AND FINDINGS: This evaluation is based on 2000-2007 data, including 453,407,458 individual reimbursement data records and incidence of flu-like syndromes FLSs. Data were obtained from the computerized French National Health Insurance database and provided by the French Sentinel Network. As compared to the preintervention period 2000-2002, the total number of antibiotic prescriptions per 100 inhabitants, adjusted for FLS frequency during the winter season, changed by -26.5% 95% confidence interval CI -33.5% to -19.6% over 5 years. The decline occurred in all 22 regions of France and affected all antibiotic therapeutic classes except quinolones. The greatest decrease -35.8% 95% CI -48.3% to -23.2%, was observed among young children aged 6-15 years. A significant change of -45% in the relationship between the incidence of flu-like syndromes and antibiotic prescriptions was observed. CONCLUSIONS: The French national campaign was associated with a marked reduction of unnecessary antibiotic prescriptions, particularly in children. This study provides a useful method for assessing public-health strategies designed to reduce antibiotic use.

Author: Elifsu Sabuncu - Julie David - Claire Bernède-Bauduin - Sophie Pépin - Michel Leroy - Pierre-Yves Boëlle - Laurence Watier - D



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