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Oxidative Medicine and Cellular Longevity - Volume 2016 2016, Article ID 3173564, 15 pages -

Research Article

Institute of Biological Sciences, Laboratory of Functional and Structural Biology, Federal University of Pará, 66075-900 Belém, PA, Brazil

Institute of Biological Sciences, Laboratory of Experimental Neuroprotection and Neuroregeneration, Federal University of Pará, 66075-900 Belém, PA, Brazil

Received 22 July 2016; Revised 26 September 2016; Accepted 12 October 2016

Academic Editor: Michael D. Coleman

Copyright © 2016 Rafael R. Lima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Stroke is a leading cause of death and neurological disability worldwide and striatal ischemic stroke is frequent in humans due to obstruction of middle cerebral artery. Several pathological events underlie damage progression and a comprehensive description of the pathological features following experimental stroke in both acute and chronic survival times is a necessary step for further functional studies. Here, we explored the patterns of microglial activation, astrocytosis, oligodendrocyte damage, myelin impairment, and Nogo-A immunoreactivity between 3 and 30 postlesion days PLDs after experimental striatal stroke in adult rats induced by microinjections of endothelin-1 ET-1. The focal ischemia induced tissue loss concomitant with intense microglia activation between 3 and 14 PLDs maximum at 7 PLDs, decreasing afterward. Astrocytosis was maximum around 7 PLDs. Oligodendrocyte damage and Nogo-A upregulation were higher at 3 PLDs. Myelin impairment was maximum between 7 and 14 PLDs. Nogo-A expression was higher in the first week in comparison to control. The results add important histopathological features of ET-1 induced stroke in subacute and chronic survival times. In addition, the establishment of the temporal evolution of these neuropathological events is an important step for future studies seeking suitable neuroprotective drugs targeting neuroinflammation and white matter damage.





Autor: Rafael R. Lima, Luana N. S. Santana, Rafael M. Fernandes, Elder M. Nascimento, Ana Carolina A. Oliveira, Luanna M. P. Fernand

Fuente: https://www.hindawi.com/



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