Evaluation of Serum Fibrinogen, Plasminogen, α2-Anti-Plasmin, and Plasminogen Activator Inhibitor Levels PAI and Their Correlation with Presence of Retinopathy in Patients with Type 1 DMReportar como inadecuado




Evaluation of Serum Fibrinogen, Plasminogen, α2-Anti-Plasmin, and Plasminogen Activator Inhibitor Levels PAI and Their Correlation with Presence of Retinopathy in Patients with Type 1 DM - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of Diabetes Research - Volume 2014 2014, Article ID 317292, 6 pages -

Research Article

Endocrinology and Metabolism Department, Ataturk Training and Research Hospital, Yildirim Beyazit University, 6800 Ankara, Turkey

Ophthalmology Department, Ataturk Training and Research Hospital, Yildirim Beyazit University, Ankara, Turkey

Ophtalmology Department, Izzet Baysal Government Hospital, Bolu, Turkey

Department of Biochemistry, Ataturk Training and Research Hospital, Yildirim Beyazit University, Ankara, Turkey

Received 10 March 2014; Accepted 16 March 2014; Published 10 April 2014

Academic Editor: Nikolaos Papanas

Copyright © 2014 Sefika Burcak Polat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Diabetic retinopathy DR is the leading cause of blindness in the world. Retinopathy can still progress despite optimal metabolic control. The aim of the study was to determine whether different degrees of DR proliferative or nonproliferative were associated with abnormally modulated hemostatic parameters in patients with T1DM. Method. 52 T1DM patients and 40 healthy controls were enrolled in the study. Patients were subdivided into three categories. Group I was defined as those without retinopathy, group II with NPRP, and group III with PRP. We compared these subgroups with each other and the control group Group IV according to the serum fibrinogen, plasminogen, alpha2-anti-plasmin α2-anti-plasmin, and PAI. Results. We detected that PAI-1, serum fibrinogen, and plasminogen levels were similar between the diabetic and control groups , , and , resp., whereas α2-anti-plasmin was higher in Groups I, II, and III compared to the control group , , and , resp

There was a positive correlation between serum α2-anti-plasmin and HbA1c levels , . Conclusion. To our knowledge there is scarce data in the literature about α2-anti-plasmin levels in type 1 diabetes. A positive correlation between α2-anti-plasmin with HbA1c suggests that fibrinolytic markers may improve with disease regulation and better glycemic control.





Autor: Sefika Burcak Polat, Nagihan Ugurlu, Fatma Yulek, Huseyin Simavli, Reyhan Ersoy, Bekir Cakir, and Ozcan Erel

Fuente: https://www.hindawi.com/



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