Patterns of hippocampal-neocortical interactions in the retrieval of episodic autobiographical memories across the entire life-span of aged adults.: Hippocampal-neocortical interactions during EAM retrievalReportar como inadecuado




Patterns of hippocampal-neocortical interactions in the retrieval of episodic autobiographical memories across the entire life-span of aged adults.: Hippocampal-neocortical interactions during EAM retrieval - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

* Corresponding author 1 Neuropsychologie cognitive et neuroanatomie fonctionnelles de la mémoire 2 LPNCog - Laboratoire de Psychologie et Neurosciences Cognitives

Abstract : We previously demonstrated that episodic autobiographical memories EAMs rely on a network of brain regions comprising the medial temporal lobe MTL and distributed neocortical regions regardless of their remoteness. The findings supported the model of memory consolidation, which proposes a permanent role of MTL during EAM retrieval multiple-trace theory or MTT rather than a temporary role standard model. Our present aim was to expand the results by examining the interactions between the MTL and neocortical regions or MTL-neocortical links during EAM retrieval with varying retention intervals. We used an experimental paradigm specially designed to engage aged participants in the recollection of EAMs, extracted from five different time-periods, covering their whole life-span, in order to examine correlations between activation in the MTL and neocortical regions. The nature of the memories was checked at debriefing by means of behavioral measures to control the degree of episodicity and properties of memories. Targeted correlational analyses carried out on the MTL, frontal, lateral temporal, and posterior regions revealed strong links between the MTL and neocortex during the retrieval of both recent and remote EAMs, challenging the standard model of memory consolidation and supporting MTT instead. Further confirmation was given by results showing that activation in the left and right hippocampi significantly correlated during the retrieval of both recent and remote memories. Correlations among extra-MTL neocortical regions also emerged for all time-periods, confirming the critical role of the prefrontal, temporal lateral temporal cortex and temporal pole, precuneus, and posterior cingulate regions in EAM retrieval. Overall, this paper emphasizes the role of a bilateral network of MTL and neocortical areas whose activation correlate during the recollection of rich phenomenological recent and remote EAMs.

keyword : autobiographical memory consolidation correlation hippocampus neuroimaging





Autor: Armelle Viard - Karine Lebreton - Gaël Chételat - Béatrice Desgranges - Brigitte Landeau - Alan Young - Vincent De La Sayette

Fuente: https://hal.archives-ouvertes.fr/



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