The insertion-deletion I-D polymorphism in the Angiotensin-converting enzyme gene and cancer risk: a meta-analysisReportar como inadecuado




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BMC Medical Genetics

, 12:159

Genetic epidemiology and genetic associations

Abstract

BackgroundThe insertion-deletion I-D polymorphism in the Angiotensin-converting enzyme ACE gene has been implicated in susceptibility to cancer, but a large number of studies have reported inconclusive results. The aim of this study is to assess the association between the I-D polymorphism in the ACE gene and cancer risk by meta-analysis.

MethodsA search was performed in Pubmed database, Embase database, Chinese Biomedical CBM database, China National Knowledge Infrastructure CNKI database and Weipu database, covering all studies until August 31, 2010. Statistical analysis was performed by using Revman4.2 and STATA 10.0.

ResultsA total of 25 case-control studies comprising 3914 cancer patients and 11391 controls were identified. No significant association was found between the I-D polymorphism and over all cancer risks OR = 0.88, 95%CI = 0.73-1.06, P = 0.17 for DD+DI vs. II. In the subgroup analysis by ethnicity, no significant association was found among Asians and Europeans for the comparison of DD+DI vs. II. In the subgroup analysis by cancer types, no significant associations were found among lung cancer, breast cancer, prostate cancer, colorectal cancer, gastric cancer for the comparison of DD+DI vs. II. Results from other comparative genetic models also indicated the lack of associations between this polymorphism and cancer risks.

ConclusionsThis meta-analysis suggested that the ACE D-I polymorphism might not contribute to the risk of cancer.

KeywordsAngiotensin-converting enzyme cancer meta-analysis polymorphism risk Electronic supplementary materialThe online version of this article doi:10.1186-1471-2350-12-159 contains supplementary material, which is available to authorized users.

Yonggang Zhang, Jie He, Yao Deng, Jie Zhang contributed equally to this work.

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Autor: Yonggang Zhang - Jie He - Yao Deng - Jie Zhang - Xiaobo Li - Zhangpeng Xiang - Honglang Huang - Can Tian - Jin Huang - Ho

Fuente: https://link.springer.com/







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