Age-dependent alteration of TGF-β signalling in osteoarthritisReportar como inadecuado

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Cell and Tissue Research

, Volume 347, Issue 1, pp 257–265

First Online: 04 June 2011Received: 04 April 2011Accepted: 06 May 2011


Osteoarthritis OA is a disease of articular cartilage, with aging as the main risk factor. In OA, changes in chondrocytes lead to the autolytic destruction of cartilage. Transforming growth factor-β has recently been demonstrated to signal not only via activin receptor-like kinase 5 ALK5-induced Smad2-3 phosphorylation, but also via ALK1-induced Smad1-5-8 phosphorylation in articular cartilage. In aging cartilage and experimental OA, the ratio ALK1-ALK5 has been found to be increased, and the expression of ALK1 is correlated with matrix metalloproteinase-13 expression. The age-dependent shift towards Smad1-5-8 signalling might trigger the differentiation of articular chondrocytes with an autolytic phenotype.

KeywordsAging Bone morphogenetic protein Osteoarthritis Osteophyte Signalling Smad Transforming growth factor-β This work was supported by The Netherlands Organization for Scientific Research MW-NWO and the Centre for Biomedical Genetics.

The authors declare no conflicts of interest.

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Autor: Peter M. van der Kraan - Marie-José Goumans - Esmeralda Blaney Davidson - Peter ten Dijke


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