Tumor recognition following Vgamma9Vdelta2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I.Reportar como inadecuado




Tumor recognition following Vgamma9Vdelta2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

* Corresponding author 1 Interactions récepteurs ligands en immunocancérologie et immunopathologie 2 Centre de Physiopathologie Toulouse Purpan 3 Departement of Biochemistry, Biozentrum 4 IPBS - Institut de pharmacologie et de biologie structurale 5 IFRLB - IFR Louis Bugnard

Abstract : Vgamma9Vdelta2 T lymphocytes, a major gammadelta T lymphocyte subset in humans, display cytolytic activity against various tumor cells upon recognition of yet uncharacterized structures. Here, we show that an entity related to the mitochondrial F1-ATPase is expressed on tumor cell surface and promotes tumor recognition by Vgamma9Vdelta2 T cells. When immobilized, purified F1-ATPase induces selective activation of this lymphocyte subset. The Vgamma9Vdelta2 T cell receptors TCR and the F1-ATPase also bind a delipidated form of apolipoprotein A-I apo A-I, as demonstrated by surface plasmon resonance. Moreover, the presence of apo A-I in the culture medium is required for optimal activation of Vgamma9Vdelta2 T cells by tumors expressing F1-ATPase. This study thus describes an unanticipated tumor recognition mechanism by Vgamma9Vdelta2 lymphocytes and a possible link between gammadelta T cell immunity and lipid metabolism.





Autor: Emmanuel Scotet - Laurent Martinez - Ethan Grant - Ronald Barbaras - Paul Jenö - Martine Guiraud - Bernard Monsarrat - Xavier Sa

Fuente: https://hal.archives-ouvertes.fr/



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