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, Volume 14, Issue 1, pp 63–70

First Online: 09 December 2012Received: 12 June 2012Accepted: 18 November 2012


The widely studied SH-SY5Y human neuroblastoma cell line provides a classic example of how a cancer cell line can be instrumental for discoveries of broad biological and clinical significance. An important feature of the SH-SY5Y cells is their ability to differentiate into a functionally mature neuronal phenotype. This property has conferred them the potential to be used as an in vitro model for studies of neurodegenerative and neurodevelopmental disorders. Here, we present a comprehensive assessment of the SH-SY5Y cytogenomic profile. Our results advocate for molecular cytogenetic data to inform the use of cancer cell lines in research.

KeywordsSH-SY5Y Neuroblastoma Cytogenomic Neuronal Model Molecular cytogenetics Karyotype  Download fulltext PDF

Autor: Mohammed Yusuf - Kay Leung - Keith J. Morris - Emanuela V. Volpi


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