Increased Excretion of C4-Carnitine Species after a Therapeutic Acetylsalicylic Acid Dose: Evidence for an Inhibitory Effect on Short-Chain Fatty Acid MetabolismReportar como inadecuado




Increased Excretion of C4-Carnitine Species after a Therapeutic Acetylsalicylic Acid Dose: Evidence for an Inhibitory Effect on Short-Chain Fatty Acid Metabolism - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

ISRN PharmacologyVolume 2011 2011, Article ID 851870, 8 pages

Research ArticleCentre for Human Metabonomics, North-West University Potchefstroom Campus, Private Bag X6001, Potchefstroom 2522, South Africa

Received 30 November 2010; Accepted 13 January 2011

Academic Editors: J. C. Laguna and A. Zhang

Copyright © 2011 Catharina M. C. Mels et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Acetylsalicylic acid and-or its metabolites are implicated to have various effects on metabolism and, especially, on mitochondrial function. These effects include both inhibitory and stimulatory effects. We investigated the effect of both combined and separate oral acetylsalicylic acid and acetaminophen administration at therapeutic doses on the urinary metabolite profile of human subjects. In this paper, we provided in vivo evidence, in human subjects, of a statistically significant increase in isobutyrylcarnitine after the administration of a therapeutic dose of acetylsalicylic acid. We, therefore, propose an inhibitory effect of acetylsalicylic acid on the short-chain fatty acid metabolism, possibly at the level of isobutyryl-CoA dehydrogenase.





Autor: Catharina M. C. Mels, Peet Jansen van Rensburg, Francois H. van der Westhuizen, Pieter J. Pretorius, and Elardus Erasmus

Fuente: https://www.hindawi.com/



DESCARGAR PDF




Documentos relacionados