Intellectual, Mnemonic, and Frontal Functions in Dementia with Lewy Bodies: A Comparison with Early and Advanced Parkinson’s DiseaseReportar como inadecuado




Intellectual, Mnemonic, and Frontal Functions in Dementia with Lewy Bodies: A Comparison with Early and Advanced Parkinson’s Disease - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Behavioural Neurology - Volume 11 1999, Issue 3, Pages 173-183



Department of Psychology, University of Liverpool, UK

The Walton Centre for Neurology and Neurosurgery, Liverpool, UK

Received 1 February 1999; Accepted 1 February 1999

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Both Parkinson’s disease PD and dementia with Lewy bodies DLB share a common neuropathological marker, the presence of Lewy bodies in brain stem and basal forebrain nuclei. DLB, in addition, is associated with Lewy bodies in the neocortex, and, in it’s more common form, with Alzheimer-type pathological markers, particularly amyloid plaques. Published neuropsychological studies have focused on the differential profiles of DLB and Alzheimer’s disease AD. However, it is presently unclear whether DLB should be classified as a variant of AD or PD. In the present study we compare a healthy age-matched control group with three groups of patients, one with DLB, and two with PD. One of the PD groups was early in the course PD-E and the second, more advanced group PD-A, was matched on severity of cognitive impairment with the DLB group. The results show that DLB was associated with a different pattern of neuropsychological impairment than the PD-A group, particularly in tests believed to be mediated by prefrontal cortical regions.





Autor: John Joseph Downes, Nicholas M. Priestley, Mark Doran, Jose Ferran, Eric Ghadiali, and Paul Cooper

Fuente: https://www.hindawi.com/



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